Feedback loops between DNMT1 and autophagy as well as senescence promotes organ aging and canities.

Lu Li, Xinyue Mao, Linda Xiaoyan Li, Huaping Xiao, Zhenkun Lou, Hongbo Liu, Julie Xia Zhou, Li Yao, Xiaogang Li

Department of Medicine, Mayo Clinic, Rochester, MN, USA.Department of Medicine, Mayo Clinic, Rochester, MN, USA. · pubmed

Paper

Abstract

Alternations of DNA methylation occur in aging, which is regulated by DNA methyltransferases (DNMTs). In this study, we show that even though the transcription of DNMT1, the only enzyme that maintains DNA methylation in the mammalian genome, is reported to be decreased in an age-dependent manner, the decrease of

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that feedback loops between DNMT1 and autophagy, as well as senescence, promote organ aging and canities. This research addresses mechanisms that may contribute to the root causes of aging, particularly through the regulation of DNA methylation and cellular processes involved in aging.

Author of this paper? Send a correction.