FASN mediates crosstalk between autophagy and lipid metabolism via the AMPK-MTOR pathway in early age-related macular degeneration.

Jinyu Cai, Yanmei Jiang, Xingyu Liu, Tao Yang, Peizeng Yang, Ling Chen

Ophthalmology Medical Center, Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, Chongqing Branch (Municipality Division) of National Clinical Research Centre for Ocular Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. · pubmed

Paper

Abstract

Age-related macular degeneration (AMD) involves sub-retinal pigment epithelium (sub-RPE) lipid deposition in the early stage, with dysregulated lipid metabolism and impaired macroautophagy/autophagy implicated, yet the molecular mechanisms underlying their interaction remain unclear. In this study, transcriptomic analysis of human macular tissues identified FASN (fatty acid synthase), a regulator of lipid metabolism and lysosomal function, as a significantly upregulated key hub gene in early AMD. In

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Research summary

FASN mediates the interaction between autophagy and lipid metabolism in early age-related macular degeneration. The study addresses the molecular mechanisms underlying lipid metabolism and autophagy, which are crucial in the context of aging and age-related diseases.

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