A RANKL

Jinbo Li, Jinxiao Fan, Zhenqiang Yao, Han Jiao, Rong Duan, James O Sanders, Addisu Mesfin, Lianping Xing, Brendan F Boyce

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. [email protected]. · pubmed

Paper

Abstract

RANKL induces bone loss in part by promoting degradation of TRAF3, levels of which decrease in murine and human bone during aging, but the major cellular sources of RANKL in bone marrow (BM) during aging are unknown. Here, we identify RANKL

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Research summary

RANKL promotes bone loss by degrading TRAF3, which decreases in bone during aging. The study addresses a mechanism related to bone health in aging, which is a significant aspect of longevity research.

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