β-caryophyllene, a CB2-selective phytocannabinoid, differentially modulates attention and inhibitory control in low- and high-performing young and aged mice.

Williams M N, Patel N T, Fleischel E J, Wimmer M E, Ward S J, Parikh V

Department of Psychology and Neuroscience, Temple University, 1701 N. 13th Street, Philadelphia, PA, 19122, USA.Department of Psychology and Neuroscience, Temple University, 1701 N. 13th Street, Philadelphia, PA, 19122, USA. · pubmed

Paper

Abstract

Evidence suggests that modulation of cannabinoid signaling via CB2 receptors regulates neuroinflammation and confers neuroprotection, positioning these receptors as promising targets for age-related cognitive decline. However, there are limited studies that have directly explored the effects of acute CB2 receptor activation on cognitive domains impacted in aging.

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Research summary

The paper claims that β-caryophyllene, a CB2-selective phytocannabinoid, can differentially modulate attention and inhibitory control in young and aged mice. This research is relevant as it explores the potential of cannabinoid signaling in addressing cognitive decline associated with aging, which aligns with the broader goals of longevity research.

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