Alleviation of diabetic cardiomyopathy via preventing VCAM1-positive cells from senescence by engineered nanovesicles.

Yang Liu, Shuang Liang, Fan Bu, Pengying Wu, Xueying Zhou, Jing Zhao, Mingzhi Shen, Mengying Wei, Guodong Yang, Lijun Yuan

Department of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. · pubmed

Paper

Abstract

Diabetic cardiomyopathy (DCM) involves progressive cardiac dysfunction driven by vascular endothelial injury and cellular senescence. However, precisely targeting pre-senescent cells remains a major therapeutic challenge. Herein, through single-cell RNA sequencing of diabetic mouse hearts, we identified VCAM1 -positive (VCAM1

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Research summary

The paper claims that engineered nanovesicles can prevent VCAM1-positive cells from senescence, alleviating diabetic cardiomyopathy. This research addresses cellular senescence, a key factor in aging and age-related diseases, making it relevant to longevity.

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