Evidence for negative selection against somatic mutations induced in normal fibroblasts by

Ronald Cutler, Johanna Heid, Shixiang Sun, Moonsook Lee, Alex Maslov, Lei Zhang, Simone Sidoli, Xiao Dong, Jan Vijg

Albert Einstein College of Medicine; [email protected] Einstein College of Medicine; [email protected]. · pubmed

Abstract

Mutations accumulate with age in most human tissues. While some undergo clonal expansion and contribute to disease, the mutational burden tolerated by a normal cell without functional decline remains unknown. Here, we repeatedly treat proliferating human primary fibroblasts with the point mutagen

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that there is negative selection against somatic mutations in normal fibroblasts. This research is relevant as it explores the mutational burden in normal cells, which is crucial for understanding cellular aging and its implications for longevity.

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