Foundations of Gerophysics.

Maximilian Unfried, Weihan Huai, Kamil Pabis, Sandra Jose, Zhi Meng Lim, Uri Alon, Marija Cvijovic, Nir Eynon, Peter Fedichev, Yumi Kim, Leong Kim Whye, Csaba Kerepesi, Woon-Puay Koh, Dmitrii Kriukov, Matt Kaeberlein, Feng Ling, Glen Pridham, Michael Rera, Steffen Rulands, Andrew Rutenberg, Kumar Selvarajoo, Ben Shenhar, Morten Scheibye-Knudsen, Andrei E Tarkhov, Andrew Teschendorff, Weilan Wang, Ee Hou Yong, Yifan Yang, Jan Gruber, Brian K Kennedy

Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore 117456, Singapore. · pubmed

Paper

Abstract

The inaugural Global Conference on Gerophysics convened 160 researchers across physics, biology, computation, and medicine in Singapore on March 5-6, 2025. With 31 speakers, the two-day event explored how physical laws, and quantitative principles unify aging science, linking biological processes to longevity patterns. Sessions covered diverse aging aspects, from developmental stages to species comparisons. The meeting showcased innovative methods to study aging, emphasizing data-driven insights. A central theme was bridging theory and experiment to advance understanding. It concluded with a consensus around (1) shared multi-modal datasets; (2) physics-based definitions for "aging", "rejuvenation", and "healthspan"; (3) models predicting intervention outcomes; and (4) translational links between non-human species and human research. These priorities outline a practical path for a quantitative, predictive Gerophysics, building on the 2025 conference's insights to shape future aging research.

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Research summary

The paper proposes a framework for understanding aging through the lens of physical laws and quantitative principles. This research is relevant as it seeks to unify various scientific disciplines to address the fundamental mechanisms of aging, rather than merely treating age-related diseases.

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