ACE-inhibitory peptide Leu-Tyr-Ala in skeletal muscle actin exhibits anti-aging effects through the inhibition of acn-1 in Caenorhabditis elegans.
Abstract
Inhibitors of angiotensin-converting enzyme (ACE) are used in pharmaceuticals and functional foods. Captopril, a well-known ACE inhibitor, extends the lifespan of the nematode Caenorhabditis elegans. Bioactive peptides derived from food sources are considered safe ACE inhibitors. Previously, we identified the sequence Asp-Leu-Tyr-Ala in skeletal muscle actin and its derivatives, Leu-Tyr-Ala, Leu-Tyr, and Tyr-Ala, as antioxidant peptides. In the present study, we evaluated the ACE-inhibitory activity of peptides and their anti-aging effects in a C. elegans model.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper claims that the ACE-inhibitory peptide Leu-Tyr-Ala exhibits anti-aging effects through the inhibition of acn-1 in C. elegans. The study investigates a potential mechanism for lifespan extension, which is directly related to aging and longevity.
Author of this paper? Send a correction.