Prelamin A in an

Yuexia Wang, Leroy C Joseph, Cecilia Östlund, George Kuriakose, Wei Hsu, Susan Michaelis, Howard J Worman

Department of Medicine (Y.W., L.C.J., C.O., G.K., H.J.W.), Vagelos College of Physicians and Surgeons, Columbia University, NY. · pubmed

Paper

Abstract

Hutchinson-Gilford progeria syndrome is an accelerated aging disorder characterized by numerous symptoms, including early onset atherosclerosis, myocardial infarctions, and strokes. Hutchinson-Gilford progeria syndrome is caused by mutations in

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the role of prelamin A in Hutchinson-Gilford progeria syndrome, suggesting a link between this protein and accelerated aging processes. This research is relevant as it addresses a genetic cause of aging-related disorders, potentially offering insights into the mechanisms of aging itself.

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