Impact of 14 weeks combined exercise on serum cadmium levels, DNA methylation, and epigenetic aging in older women.

Guilherme da Silva Rodrigues, Natalia Yumi Noronha, João Gabriel Ribeiro de Lima, Chanachai Sae-Lee, Pitaksin Chitta, Andressa Crystine da Silva Sobrinho, Isabella Harumi Yonehara Noma, Luísa Maria Diani, Fernando Barbosa Júnior, Carla Barbosa Nonino, Lígia Moriguchi Watanabe, Carlos Roberto Bueno Júnior

Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. · pubmed

Paper

Abstract

Cadmium is a toxic heavy metal linked to impaired cardiorespiratory fitness and altered DNA methylation patterns. This study investigated the effects of 14 weeks of combined exercise training on epigenetic modifications and blood cadmium levels in women with varying aerobic fitness.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that 14 weeks of combined exercise training can reduce serum cadmium levels and influence DNA methylation in older women. This study is relevant as it explores the intersection of exercise, toxic exposure, and epigenetic changes, which may contribute to understanding mechanisms of aging and longevity.

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