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RESEARCH PAPER / 2026-05-14

Sleep chart of biological ageing clocks in middle and late life.

Cliodhna Kate O'Toole, Zhiyuan Song, Filippos Anagnostakis, Zhijian Yang, Ye Ella Tian, Michael R Duggan, Chunrui Zou, Yue Leng, Yi Cai, Wenjia Bai, Cynthia H Y Fu, Michael S Rafii, Paul Aisen, Gao Wang, Philip L De Jager, Jian Zeng, Hamilton Se-Hwee Oh, Xia Zhou, Keenan A Walker, Daniel W Belsky, Andrew Zalesky, Eleanor M Simonsick, Susan M Resnick, Luigi Ferrucci, Christos Davatzikos, Junhao Wen

Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA. · pubmed

Abstract

Optimal sleep has a vital role in promoting healthy ageing and enhancing longevity. Here we propose Sleep Chart to assess the relationship between self-reported sleep duration and 23 biological ageing clocks derived from in vivo imaging

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper proposes a Sleep Chart to assess the relationship between self-reported sleep duration and biological ageing clocks. The focus on sleep's role in healthy ageing and longevity aligns with research aimed at understanding and potentially mitigating the root causes of aging.

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