Dpp and immune response pathway factors mediate paracrine induction of senescent cells in

Abstract

Transition toward senescence is a cellular response to various forms of stress. This phenomenon is evolutionarily conserved across species, from insects to humans. Senescent cells (SCs) permanently withdraw from the cell cycle and undergo physiological changes, notably the acquisition of a robust secretory activity characterized by the release of numerous molecules, including cytokines, chemokines, and metalloproteinases. Through this program, termed Senescence-Associated Secretory Phenotype, SCs communicate with and influence their microenvironment. In mammalian tissues, the number of SCs increases with age and their accumulation has been proposed to contribute to age-associated pathologies. Studies in vertebrate systems have demonstrated that new SCs can arise through paracrine signaling from preexisting SCs, a process that requires the activity of the Transforming Growth Factor β (TGF-β). We have investigated the occurrence of paracrine recruitment of SCs in the fruitfly