Rogue gut microbes derail memory.
Abstract
The gut microbiome contributes to age-related cognitive decline, but signaling mechanisms remain unclear. In a recent issue of Nature, Cox et al. show that P. goldsteinii-derived fatty acids activate myeloid cells, thus inducing inflammation that disrupts vagal signaling and hippocampal memory encoding.
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Research summary
P. goldsteinii-derived fatty acids activate myeloid cells, inducing inflammation that disrupts vagal signaling and hippocampal memory encoding. This research addresses the role of gut microbiome-induced inflammation in cognitive decline, which is a significant aspect of aging and age-related cognitive disorders.
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