Urolithin A: A Novel Postbiotic for inflammation, aging, and cancer: A Journey from Dietary ellagitannins to clinical use.

Saniya Thakur, M V N L Chaitanya, Sachin Kumar Singh, Navneet Khurana, Jubie Selvaraj, Arya Lakshmi M, Avijit Mazumder, Pallav Sengupta

School of Pharmaceutical sciences, Lovely Professional university, Jalandhar - Delhi, Grand Trunk Rd, Phagwara, 144411, Punjab, India. · pubmed

Paper

Abstract

Urolithin A (UA) is synthesized when the body metabolizes ellagic acid and ellagitannins. UA has been a widely recognized physiologically active compound throughout the previous decade. The gut microbiota affects metabolic regulators AMPK and sirtuins, initiates autophagy, and activates mitochondrial quality control, which is essential for infection resistance, intestinal health, and inflammation reduction.

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Research summary

Urolithin A may enhance mitochondrial function and autophagy, potentially addressing mechanisms of aging. The paper discusses a compound that could influence fundamental biological processes related to aging and inflammation, making it relevant to longevity research.

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