The effect of dehydroepiandrosterone on the vascular system: role of H

Carlotta Turnaturi, Chiara Indolfi, Melania Correale, Erika Esposito, Anna Schettino, Valentina Vellecco, Raffaella Sorrentino, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca

INSERM U1148-LVTS, Université de Paris, Paris, France. · pubmed

Paper

Abstract

Dehydroepiandrosterone (DHEA) is an adrenal steroid hormone that serves as a precursor to androgens and estrogens and participates in several physiological processes. Its levels naturally decline with age, and reduced DHEA concentrations have been associated with an increased risk of cardiovascular disease. However, this relationship is complex, and further research is required to clarify whether DHEA supplementation may help to prevent age-related vascular dysfunction. Here, we investigated the vascular effects of DHEA using mouse aorta and bovine aortic endothelial cells (BAEC), focusing on the potential involvement of hydrogen sulfide (H

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Research summary

The paper investigates the vascular effects of DHEA and its potential role in preventing age-related vascular dysfunction. The study addresses a hormone whose decline is associated with aging and cardiovascular disease, thus linking it to longevity research.

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