Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes.

Raquel Gómez-Sintes, Inmaculada Tasset, Ignacio Ramírez-Pardo, Adrián Martín-Segura, Sandra Alonso-Gil, Antonio Díaz, Kristen Lindenau, Concepción Lillo, Pedro de la Villa, Simone Sidoli, Evripidis Gavathiotis, Ana María Cuervo, Patricia Boya

Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas, Consejo superior de Investigaciones Científicas (CSIC), Madrid 28040, Spain. · pubmed

Paper

Abstract

Defective proteostasis is a hallmark of aging cells and tissues. Among the different components of the proteostasis network, in this study, we focus on a selective form of autophagy known as chaperone-mediated autophagy (CMA), and we set out to understand its physiological role in the retina. Using mice deficient for CMA [knockout for lysosome-associated membrane protein type 2A (

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Research summary

Chaperone-mediated autophagy plays a protective role against retinal photoreceptor degeneration by modulating the proteostasis of glucose metabolism enzymes. The study addresses the mechanisms of proteostasis, which are crucial for understanding aging processes and potential interventions for age-related degeneration.

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