Dyslipidemia as a key nexus linking depression and aging acceleration: unraveling the mediating role of lipid accumulation product (LAP).

Li Zhang, QianKun Yang, ChunMei Xu, Yue Hu, Li Xiao, Jie Yu

Department of Hematology and Oncology of Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases' Ministry of Education Key Laboratory of Child Development and Disorders' Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, No.136 of Zhongshan Second road' YuZhong District, Chongqing, 400014, China. · pubmed

Paper

Abstract

Although depression and biological aging share dyslipidemia as a common pathological feature, the extent to which dyslipidemia is involved in their association remains unclear. This study aimed to explore the association between depressive symptoms and accelerated biological aging, with a particular focus on whether dyslipidemia, as measured by the lipid accumulation product (LAP), statistically mediates this association.

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Research summary

Dyslipidemia mediates the association between depressive symptoms and accelerated biological aging. This paper is relevant as it explores a potential underlying mechanism linking dyslipidemia, depression, and biological aging, which could inform strategies for addressing root causes of aging.

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