Modulation of mitochondrial DNA copy number: therapeutic potential of phytochemicals and plant extracts-a comprehensive review.

Maria Rosaria Perri, Annamaria Cerantonio, Maria Grazia Cipriani, Ida Manna, Anna Aureli, Beatrice Marziani, Francesco Andreozzi, Gaia Chiara Mannino, Elettra Mancuso, Carolina Averta, Giancarlo Statti, Luigi Citrigno, Davide Mainieri

National Research Council, Institute for Agriculture and Forestry System in the Mediterranean (CNR-ISAFoM), Rende, CS, Italy.National Research Council, Institute for Agriculture and Forestry System in the Mediterranean (CNR-ISAFoM), Rende, CS, Italy. · pubmed

Paper

Abstract

Mitochondrial DNA copy number (mtDNA-CN) is a critical marker of mitochondrial health and plays a key role in cellular bioenergetics. Alterations in mtDNA-CN have been associated with aging, metabolic disorders and neurodegenerative diseases. Recent studies have revealed that various plant-derived extracts, as well as the secondary metabolites they produce, known as phytochemicals, can modulate mtDNA-CN through mechanisms including the regulation of mitochondrial biogenesis, oxidative stress, and mtDNA repair. This review examines plant-derived extracts and phytochemical compounds from a wide range of plant species- including Ginkgo biloba, Crocus sativus, Curcumin and many others- able to modulate mtDNA dynamics, scavenging oxygen free radicals and improving antioxidant defense systems.

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Research summary

Phytochemicals and plant extracts can modulate mitochondrial DNA copy number, potentially influencing aging and age-related diseases. The paper is relevant as it explores mechanisms that may address mitochondrial health, which is a critical factor in the aging process.

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