Plasma glycine decelerates biological aging via the redox-inflammatory axis: A large-scale study modulated by sex and dietary patterns.

Huan Xu, Sijia Pan, Haitao Qi, Xingyu Liu, Guannan Geng, Xiang Qi, Wei Wei, Ying Li, Xuanyang Wang

Department of Clinical Nutrition, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. · pubmed

Paper

Abstract

Glycine serves as a critical substrate for glutathione synthesis and a critical modulator of redox homeostasis. However, whether plasma glycine is associated with biological aging, and the underlying interplay between oxidative stress, inflammation, and dietary context remains unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Plasma glycine levels are associated with biological aging markers through redox-inflammatory pathways, modulated by sex and diet. The study is an observational association study linking a common metabolite to aging biomarkers, representing incremental epidemiological evidence rather than a mechanistic breakthrough or novel therapeutic intervention.

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