Ameliorative Effects of Butyrylated Starch on Cognitive Dysfunction in d-Galactose-Induced Aging Mice: A Comparative Analysis with Exogenous Butyrate and Resistant Starch.
Abstract
Butyric acid improves cognitive dysfunction. Therefore, butyrylated starch acts as a butyrate carrier and resistant starch to produce butyric acid, potentially improving cognitive dysfunction. In the d-galactose-induced aging mice model, BNMS2 effectively improved cognitive dysfunction and outperformed sodium butyrate and high-amylose maize starch. BNMS2 ameliorated cognitive behavior and brain histopathology, decreased GFAP, IBA-1, Aβ, AChE, MDA, IL-6, IL-1β, and TNF-α levels, and increased BDNF, PSD-5, GSH-Px, and SOD levels to mitigate neuronal damage, oxidative stress, and inflammation. BNMS2 also produced abundant butyric acid, enhanced the abundance of beneficial bacteria (
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Research summary
Butyrylated starch improves cognitive dysfunction in aging mice by acting as a butyrate carrier. The study addresses cognitive decline associated with aging, which is a significant aspect of longevity research.
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