Caloric restriction reprograms skeletal muscle molecular pathways in non-human primates: potential relevance to human aging biology.

Jayanta Kumar Das, Nirad Banskota, Stefano Donega, Nader Shehadeh, Yulan Piao, Nathan Price, Julie A Mattison, Julián Candia, Rafael de Cabo, Luigi Ferrucci

Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA. · pubmed

Paper

Abstract

Caloric restriction (CR), achieved by reducing energy intake without malnutrition, has been shown to preserve muscle function and delay age-related declines in strength and mobility by modulating key metabolic and molecular pathways involved in muscle maintenance. While most initial research on CR was done in rodents, non-human primates (NHPs) offer a higher translatable animal model for understanding CR effects due to their close genetic, physiological and cognitive similarities to humans.

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Research summary

Caloric restriction reprograms molecular pathways in skeletal muscle to preserve function and delay age-related declines. This research is relevant as it explores a potential intervention (caloric restriction) that may address the underlying mechanisms of aging and improve longevity through its effects on muscle maintenance.

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