Circulating levels of insulin-like growth factor binding protein 7 are associated with risks of chronic diseases and death.

Zhi Li, Chengzhe Tao, Ziyi Zhou, Michael N Pollak, Edward L Giovannucci, Mingyang Song

China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China. · pubmed

Paper

Abstract

Relationships between the concentration of circulating IGFBP-7 and risk of disease and mortality have been suggested by small-scale investigations. In this prospective study, we investigated these relationships among 53,003 UK Biobank participants. Higher IGFBP-7 level was significantly associated with increased risk for liver cancer, all-cause mortality, diabetes, and other diseases. Associations were robust across sex and age groups and persisted over long follow-up. IGFBP-7 polygenic risk scores also predicted cancer and mortality risk. IGFBP-7 level was strongly correlated with levels of previously identified aging-related proteins, but after adjustment for these proteins, remained associated with risk of bladder cancer, liver cancer, multiple myeloma, all-cause mortality, liver-related mortality, and diabetes. Our findings indicate IGFBP-7 as a novel biomarker of mortality and disease risk.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Higher circulating levels of IGFBP-7 are associated with increased risks of chronic diseases and mortality. The study identifies IGFBP-7 as a potential biomarker related to aging and disease risk, contributing to the understanding of factors that may influence longevity.

Author of this paper? Send a correction.