A Sepsis-Informed Model of Accelerated Aging.
Abstract
The authors sought to examine the literature for evidence of shared similar cellular impacts between sepsis and aging. There is much available literature about shared immunologic dysregulation of toll-like receptor 4 (TLR4) activity in both conditions. Based on these findings, the authors propose a model of aging inspired by the recently published (2024) OO(H)NO! model of dysregulated immune and metabolic impacts of sepsis, which directionally maps out TLR4 dysregulation in sepsis.
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Research summary
The paper proposes a model linking TLR4 dysregulation in sepsis to accelerated aging. The research explores cellular impacts that may contribute to understanding the mechanisms of aging, which is relevant to longevity studies.
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