Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling.

Jun-Ichiro Suzuki, Kiyoshi Yoshioka, Masahiro Kurita, Takumi Sugimoto, Takahiro Eguchi, Naoki Ito, Aoi Kodama, Yasutomi Kamei, Masahiro Ohtani, Toshiaki Matsutomo, Shin-Ichiro Imai

Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan. · pubmed

Paper

Abstract

Garlic (Allium sativum L.) and its aged extract contain many bioactive compounds that can bring health benefits to humans. Among them, S-1-propenyl-L-cysteine (S1PC) has recently drawn significant attention in the field of nutriceutical research. However, the mechanism of its molecular action has remained poorly understood. Here, we show that S1PC significantly activates liver kinase B1 (LKB1) through enhancing its tertiary complex formation with STRAD and MO25, leading to stimulating the phosphorylation of a mammalian NAD

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Research summary

The paper claims that the garlic-derived metabolite S-1-propenyl-L-cysteine activates LKB1, which promotes adipose eNAMPT secretion and improves age-related muscle function. This research is relevant as it explores a potential mechanism for enhancing muscle function in aging, addressing a key aspect of age-related decline.

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