Epigenetic age acceleration mediates the association between pro-inflammatory and pro-oxidant diets and the progression and mortality of cardiovascular-kidney-metabolic syndrome.

Shuang Wu, Siqi Lyu, Zhenkun Yang, Tianshu Gu, Yimeng Wang, Juan Wang, Jun Zhu, Yanmin Yang, Yang Chen, Lihui Zheng

National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. · pubmed

Paper

Abstract

The cardiovascular-kidney-metabolic (CKM) syndrome is a major public health challenge driven by intertwined cardiometabolic and renal dysfunction. Diet-related inflammation and oxidative stress may accelerate biological aging, as reflected by DNA methylation age acceleration, thereby contributing to CKM progression and mortality. However, these pathways have not been comprehensively examined.

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Research summary

The paper claims that epigenetic age acceleration mediates the relationship between pro-inflammatory and pro-oxidant diets and the progression and mortality of cardiovascular-kidney-metabolic syndrome. This research is relevant as it explores the underlying mechanisms of biological aging and how dietary factors may influence age-related diseases, potentially addressing root causes of aging.

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