Leisure-time physical activity modulates associations of sarcopenia and functional disability with mortality in older adults.

Zheng Zhu, Xu Zhou, Mingling Chen, Chun Dou, Dong Liu, Lijie Kong, Chaojie Ye, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jie Zheng, Jieli Lu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wang

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. · pubmed

Paper

Abstract

Whether physical activity modifies the associations of sarcopenia and basic/instrumental activities of daily living (ADL/IADL) disability with mortality remains unclear. The study included 64,146 participants from three nationally representative cohorts: Health and Retirement Study (HRS), Survey of Health, Aging and Retirement in Europe (SHARE), and China Health and Retirement Longitudinal Study (CHARLS). In HRS, the greater risk of mortality associated with each dysfunction was more pronounced in inactive participants, with multivariable-adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) in Cox models of 3.88 (3.57-4.23) for sarcopenia, 1.82 (1.70-1.95) for ADL disability, and 1.95 (1.81-2.09) for IADL disability, while the corresponding HRs (95% CIs) were 3.32 (2.92-3.77), 1.39 (1.20-1.61), and 1.44 (1.26-1.65) in regularly active participants (all

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Research summary

Leisure-time physical activity reduces the mortality risk associated with sarcopenia and functional disability in older adults. The paper is relevant as it explores the role of physical activity in mitigating age-related decline and mortality, addressing factors that contribute to longevity.

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