Integration of lung function in allostatic load scoring and its impact on mortality prediction.

Mohammad Azizzadeh, Emiel F M Wouters, Ahmad Karimi, Daisy J A Janssen, Bart Spaetgens, Sylvia Hartl, Robab Breyer-Kohansal, Marie-Kathrin Breyer

Ludwig Boltzmann Institute for Lung Health, Vienna, Austria. [email protected] Boltzmann Institute for Lung Health, Vienna, Austria. [email protected]. · pubmed

Paper

Abstract

Allostatic load refers to the physiological "wear and tear" that results from adaptation to stressors over the lifespan. In this study, we integrated lung function (LF) parameters into the calculation of the allostatic load score (ALS) to evaluate changes in its performance for predicting all-cause mortality. Data from 8,775 participants (aged 25-82 years; 52% female) who participated in the first wave of the Austrian LEAD cohort were used. "ALS without LF" was calculated using 12 parameters, including cardiovascular, metabolic, body composition, and bone mineral density measures. Z-scores of forced expiratory volume in 1 s (FEV

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Research summary

Integrating lung function parameters into allostatic load scoring improves mortality prediction. This study addresses physiological factors related to stress adaptation, which are relevant to understanding aging and longevity.

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