Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging.

Zhuoning Miao, Ziyang Tong, Linjing Shi, Yang Fei, Tao Zhang, Chunmei Fan, Tian Qin, Jia Gao, Qiangqiang Zheng, Xianan Mo, Hongwei Ouyang, Zi Yin, Ren Xu, Yiting Zhou, Xiao Chen

Department of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.Department of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China. · pubmed

Paper

Abstract

The aging process exhibits tissue-specific characteristics, yet its underlying mechanisms remain poorly understood. While it is widely accepted that a reduction in blood vessels in hard tissues contributes to aging, such as in osteoporosis, the vascular changes driving soft tissue aging and degeneration remain unclear. Here, by integrating single-cell transcriptomics and light-sheet imaging, we uncover a striking infiltration of type H-like blood vessels and an aging-specific Coch

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Research summary

The paper claims that targeting the coupling of type H-like vessels can influence cell fate transitions to delay soft tissue aging. This research is relevant as it explores mechanisms underlying aging and potential interventions that could address the root causes of soft tissue degeneration.

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