Biological markers of aging across the menopause transition: current evidence.

Regina Castaneda, Erin R Uddenberg, Maria D Hurtado Andrade, Jesse L Meek, Kaylin N Frankhouser, Stephanie S Faubion, Eduardo N Chini, Nathan K LeBrasseur, Pamila K Brar, Chrisandra L Shufelt

Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL.Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL. · pubmed

Paper

Abstract

Aging is a complex biological process uniquely shaped in women by hormonal transitions, particularly across the menopause transition. While chronological age alone fails to capture individual health variability, emerging molecular biomarkers offer tools to quantify biological aging and understand mechanisms underlying age-related decline. This review synthesizes the current landscape of aging biomarkers, including senescence-associated secretory phenotype factors, epigenetic clocks, clonal hematopoiesis of indeterminate potential, and telomere length, with a particular emphasis on their relevance to menopause.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper reviews various biological markers of aging and their relevance to the menopause transition. This research is relevant as it explores the biological underpinnings of aging in women, particularly in the context of hormonal changes, which could contribute to understanding and potentially addressing age-related decline.

Author of this paper? Send a correction.