Dendrobium officinale extends lifespan in yeast and Drosophila via context-dependent PI3K-AKT modulation.

Zhengqiong Sun, Min Jiang, Lei Li, Yongxing Chen, Lichun Zhao, Lei Zhang

Institute of Interdisciplinary Integrative Medicine Research, Medical College of Nantong University, Nantong, 226019, China; Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai, 200433, China.Institute of Interdisciplinary Integrative Medicine Research, Medical College of Nantong University, Nantong, 226019, China; Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai, 200433, China. · pubmed

Paper

Abstract

Dendrobium officinale Kimura et Migo (Tiepi Shihu), a yin-nourishing tonic in traditional Chinese medicine, has been historically used for health maintenance and longevity promotion.

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Research summary

Dendrobium officinale extends lifespan in yeast and Drosophila by modulating the PI3K-AKT pathway in a context-dependent manner. This paper is relevant because it investigates a specific natural compound's ability to extend lifespan in model organisms and identifies a molecular mechanism (PI3K-AKT modulation) that is central to aging biology, rather than merely treating age-related symptoms.

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