An integrated anti-aging framework targeting NAD
Abstract
As the global population ages rapidly, delaying and preventing age-related diseases have become urgent priorities in public health and biomedical research. During aging, mitochondrial dysfunction is a core molecular hallmark and a common pathogenic mechanism underlying multiple age-related disorders. Age-related mitochondrial dysfunction typically manifests as diminished metabolic capacity, impaired organelle renewal, and disrupted redox homeostasis. These factors interact to form a feedback loop constraining mitochondrial adaptability. Specifically, the interdependent decline in NAD
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Research summary
The paper proposes an integrated framework targeting NAD to address age-related mitochondrial dysfunction. This research is relevant as it aims to tackle the underlying mechanisms of aging rather than merely addressing symptoms of age-related diseases.
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