Endothelial DNA Damage Orchestrates Cardio-Kidney-Metabolic Dysfunction Through Endothelin-1 Signaling.

Wataru Ito, Ran Nakamichi, Akihito Hishikawa, Norifumi Yoshimoto, Erina Sugita Nishimura, Eriko Yoshida Hama, Tomomi Maruki, Seiei Iwabuchi, Ryuto Yoshida, Masataro Toda, Shotaro Kosugi, Shintaro Yamaguchi, Takeshi Kanda, Akinori Hashiguchi, Hiroshi Itoh, Kaori Hayashi

Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine (W.I., R.N., A. Hishikawa, N.Y., E.S.N., E.Y.H., T.M., S.I., R.Y., M.T., S.K., K.H.), Keio University School of Medicine, Tokyo, Japan. · pubmed

Paper

Abstract

Cardiovascular diseases increase with aging and are closely linked to metabolic dysfunction and kidney disease through the cardiovascular-kidney-metabolic axis, but the underlying molecular mechanisms remain unclear. Accumulating evidence suggests that vascular endothelial cells (ECs) are particularly vulnerable to aging stressors, such as DNA damage. We investigated whether EC DNA damage drives cardiovascular-kidney-metabolic dysfunction.

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Research summary

The paper claims that endothelial DNA damage drives cardiovascular-kidney-metabolic dysfunction through endothelin-1 signaling. This research is relevant as it explores the molecular mechanisms linking endothelial cell damage to age-related diseases, potentially addressing root causes of aging-related dysfunctions.

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