Paraoxonase 2 as a target for aging-related diseases.

Hyeong Hwan Kim, Ye Jin Kang, Jae Ho Lee, Hyeong Min Lee, Hyung Soon Park, Chang-Hoon Nam

Aging and Immunity Laboratory, Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea.Aging and Immunity Laboratory, Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea. · pubmed

Paper

Abstract

Paraoxonase 2 (PON2) is an enzyme exhibiting both lactonase and esterase activities, widely distributed across various tissues and localized within cellular mitochondria. It plays a vital role in innate immunity by restricting bacterial infections and has diverse functions, including the regulation of mitochondrial reactive oxygen species levels and the management of endoplasmic reticulum stress. By alleviating oxidative stress, stabilizing mitochondria, and modulating apoptosis, PON2 emerges as a significant factor in the study of cellular senescence. This review consolidates recent findings regarding PON2's physiological roles, its mechanistic connections to senescence, and the therapeutic potential of modulating its activity. Our analysis highlights PON2's considerable promise as a target for aging-related diseases, including neurodegeneration, metabolic disorders, cardiovascular diseases, chronic inflammation, and cancer.

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Research summary

PON2 modulation may provide therapeutic benefits for aging-related diseases by addressing oxidative stress and cellular senescence. The paper discusses mechanisms that connect PON2 to aging processes, which aligns with the goal of understanding and potentially mitigating the root causes of aging.

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