Cellular Senescence of Patient-derived Fibroblasts Reveals the Mid-old Stage as a Critical Window for Transcriptomic Signatures Linked to Alzheimer's Disease Biomarkers and Classification.

Young Joon Cho, Sunwoo Yoon, Yeojin Kim, Ho Min Song, You Jin Nam, Sang Hyuk Lee, Sehee Lee, Donghyuk Shin, Sun Min Lee, So Young Moon, Eun-Joo Kim, Soo Hyun Cho, Byeong C Kim, Seong Hye Choi, Sang Won Seo, Jin Cheol Kim, Young Joon Park, Hee Young Kang, Sang-Rae Lee, Sunhwa Hong, Sang Joon Son, Chang Hyung Hong, Hyun Woong Roh

Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Korea.Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Korea. · pubmed

Paper

Abstract

Alzheimer's disease (AD) is strongly associated with aging, yet the interactions remain unclear. This study modeled replicative senescence in patient-derived fibroblasts to compare gene expression between AD dementia and controls across senescence stages and to evaluate whether stage-specific alterations reflect disease characteristics with diagnostic implications.

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Research summary

The study identifies stage-specific transcriptomic alterations in patient-derived fibroblasts that may reflect Alzheimer's disease characteristics. This research is relevant as it explores the biological mechanisms of aging and their connection to Alzheimer's disease, potentially contributing to understanding age-related diseases.

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