Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin-Containing Serum: Results from a Prospective, Single-Cohort Study.

Minyue Qi, Paula Pitta, Katrin Wegner, Boris Kristof, Yan Feng, Günter Raddatz, Manuel Rodríguez-Paredes, Julia Gallinger, Rungsima Wanitphakdeedecha, Marc Winnefeld, Lilia Guadanhim, Cheri Frey, Frank Lyko, Cassandra Falckenhayn, Elke Grönniger

Research & Development, Beiersdorf AG, Hamburg, Germany.Research & Development, Beiersdorf AG, Hamburg, Germany. · pubmed

Paper

Abstract

Skin aging is driven by intrinsic and extrinsic factors. Epigenetic alterations are one primary hallmark of aging and powerful biomarkers of biological skin age. To investigate epigenetic skin aging mechanisms and their regulation as a skin longevity approach across diverse ethnicities and phototypes, we assessed epidermal methylomes from white, African, and Asian donors.

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Research summary

The paper investigates the epigenetic mechanisms of skin aging and explores a potential intervention for improving skin longevity. This research is relevant as it addresses the biological processes underlying aging and seeks to find ways to mitigate them across different ethnicities.

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