Age-dependent dysregulation of collagen metabolism in primary cardiac fibroblasts in vitro.

Kalyani Pandya, Carlos J Alcaide-Corral, Timaeus E F Morgan, Kerry O'Rourke, Leanne M Riley, Islay Cranston, Andrew Sutherland, Mark G MacAskill, Gillian A Gray, Adriana A S Tavares

Centre for Cardiovascular Science, The University of Edinburgh, UK. · pubmed

Paper

Abstract

Fibroblast-driven collagen remodelling is a key process in cardiac aging and fibrosis, yet how age and sex alter fibroblast collagen handling remains poorly characterized. This proof-of-concept study aimed to address this knowledge gap, as currently the effects of age and sex on cardiac fibroblast (cFb) collagen metabolism remain incompletely understood.

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Research summary

The paper investigates how age and sex influence collagen metabolism in cardiac fibroblasts. This research is relevant as it addresses the underlying mechanisms of cardiac aging, which is a critical aspect of longevity and age-related diseases.

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