Inflammaging in aged tissues drives remodeling of the CD8

Irina Shchukina, Carlos J Rodriguez-Hernandez, Heather S Ruiz, Maksim Kleverov, Rachel L Mintz, Katsutaka Mineura, Subhadra C Gunawardana, Sunnie Hsiung, Bishan Bhattarai, Veronika Vachova, Jan Kossl, Denis A Mogilenko, Rachael L Field, Tran H Nguyen, Quazim A Alayo, Christopher G Huckstep, Barbora Vander Wielen, Jonathan R Brestoff, Sheila A Stewart, David W Piston, Takeshi Egawa, Daniel Kreisel, Gwendalyn J Randolph, Maxim N Artyomov

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA. · pubmed

Paper

Abstract

Aging strongly impacts CD8

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that inflammaging in aged tissues leads to remodeling of CD8 T cells. This research addresses the underlying mechanisms of aging and their impact on immune function, which is relevant to understanding age-related decline and potential interventions.

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