Microcarriers encapsulating COL1A1 mRNA-loaded nanovesicles for skin photoaging treatment.

Xiang Lin, Anne M Filppula, Luoran Shang, Hongbo Zhang, Dexuan Wang

Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. · pubmed

Paper

Abstract

Extracellular vesicles have shown great potential in treating ultraviolet (UV)-induced skin photoaging. However, effective delivery of these bioactive agents to achieve long-term therapeutic effects remains a significant challenge. In this study, we have developed recombinant human collagen (RHC)-based microcarriers loaded with native exosomes as well as Collagen type I alpha 1 chain (COL1A1) mRNA-encapsulating nanovesicles (Emvs) to treat skin photoaging. The microcarriers mitigated UV-induced cellular senescence in HaCaT cells, as evidenced by reduced oxidative stress, decreased apoptosis, and attenuation of senescence-associated markers. In the animal model, the microcarriers not only attenuated wrinkle formation, but also promoted type I collagen deposition in UV-damaged skin. These results together with the demonstrated biocompatibility highlight the potential of the microcarrier delivery system in photoaging treatment.

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Research summary

The study claims that microcarriers loaded with COL1A1 mRNA-encapsulating nanovesicles can mitigate UV-induced skin photoaging. This research addresses a specific aspect of aging (skin photoaging) but does not tackle the root causes of aging or lifespan extension.

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