Single-cell gene expression and TCR profiling reveal age-related differences in recent thymic emigrants.

Cybelle Tabilas, Vanessa Venturi, Connor Kean, Anastasia Minervina, Paul G Thomas, Andrew Grimson, Jennifer K Grenier, Miles P Davenport, Norah L Smith, Brian D Rudd

Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA. · pubmed

Paper

Abstract

Following thymic egress, CD8

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that age-related differences in recent thymic emigrants can be identified through single-cell gene expression and TCR profiling. This research is relevant as it explores the mechanisms of immune aging, which is a fundamental aspect of the aging process and could inform strategies for longevity and age-related disease prevention.

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