Yeast protein improves musculoskeletal and systemic functions in mice.

Xialei Liu, Jin Luo, Yongzhao Bi, Chung-Ying Andy Lee, Shuai Liu, Yuan Ma, Shihao Sun, Lili Zhang, Jialiang Xu

Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, Beijing 100048, China. [email protected] Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, Beijing 100048, China. [email protected]. · pubmed

Paper

Abstract

Yeast protein (YP) is rich in high-quality protein and a variety of bioactive compounds and has been shown to confer beneficial effects on overall health. In this study, we systematically evaluated the comprehensive health benefits of YP in mice through a one-month dietary intervention. The results demonstrated that YP supplementation improved muscle strength, bone mineral density, bone mineral content, and the proportion of lean mass in mice. Moreover, it effectively ameliorated pathological morphology in multiple tissues and organs, alleviated fibrosis, and downregulated the expression of senescence-associated biomarkers, including SA-β-gal, p16, p53, p21, and γ-H2AX. Importantly, YP intervention modulated the gut microbiota composition, notably enriching beneficial bacteria such as

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Research summary

Yeast protein supplementation improves musculoskeletal and systemic functions in mice. The study addresses potential mechanisms of aging by evaluating the effects of yeast protein on biomarkers of senescence and overall health, which are relevant to longevity research.

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