Puerarin modulates the gut-liver-ovarian axis to ameliorate reproductive aging in breeder hens.

Zhenwu Huang, Dandan Ma, Guangju Wang, Yanru Shi, Jinghai Feng, Chunmei Li, Minhong Zhang

State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. · pubmed

Paper

Abstract

Puerarin (PU), a natural bioactive isoflavone derived from the edible root of Pueraria lobata, exhibits multi-pharmacological activities, including antioxidant, lipid metabolism-regulating, and immunomodulatory properties. The decline in the reproductive performance of hens is primarily attributed to age-related dysbiosis of gut function and reduced function of the liver-ovary axis. However, the systemic mechanisms linking puerarin-induced microbiota changes to improvements in hepatic and ovarian function in aged hens remain poorly defined. In this study, we performed a multi-omics investigation to explore the effects on gut microbiota, liver metabolism, ovarian function, and the associations among them induced by dietary puerarin in aged hens.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Puerarin improves reproductive aging in breeder hens by modulating the gut-liver-ovarian axis. This study addresses mechanisms related to aging and reproductive decline, which are relevant to understanding and potentially mitigating aspects of aging.

Author of this paper? Send a correction.