Cohort profile Davos Alzheimer's Collaborative DAC Egypt Cohort.

Sara A Moustafa, Salma Mowafi, Gharib Fawi, Mai Othman, Shimaa Heikal, Ahmed Sabry Mohamed, Hossam Habib, Omar Ahmed Hassan, Fares Meghaed, Asmaa Shaaban Youssef, Eman Mohamed Ali, Rehab Moustafa, Mahmoud Mohamed, Mahmoud Moustafa, Jana Sweilam, Malak Wahdan, Shahd Ezzeldin, Nourhan Shebl, Katren Khella, Layal Tantawi, Farah Mahmoud, Zeina Gaballah, Farah Zaki, Esraa Qansuwa, Menna El Taras, Shaimaa Sayed, Mohamed El Sayed, Ibrahim Srour, Shaimaa El Sayed Moustafa, Samra Sameer, El Sayed Gad, Mohamed Sweilam, Mie Rizig, Irene Meier, Vaibhav Narayan, Mohamed Salama

Institute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.Institute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt. · pubmed

Paper

Abstract

The Davos Alzheimer's Collaborative (DAC) Egypt Cohort (DAC-Egypt) is a newly established longitudinal study of cognitive aging in a community-based convenience sample of older Egyptian adults. The cohort's purpose is to characterize trajectories of cognitive decline and dementia risk factors in an understudied population, filling a critical gap in aging research in the Middle East. Participants (n = 1,530) aged 55 and above were recruited via regionally diverse convenience sampling, with detailed baseline data collected on demographics, health status, lifestyle, and cognitive function. Cognitive assessments included both traditional neuropsychological testing and innovative digital tools (digital voice/speech & olfactory-sensory assessments) to enable comprehensive monitoring. Key preliminary findings indicated a high prevalence of chronic diseases and notable socioeconomic disparities in cognitive performance among older Egyptians. Blood samples were collected from 98% of participants, and dried blood spot (DBS) cards were obtained for 88% of participants to facilitate future biomarker and genetic research. This study seeks to enrich the scientific field of dementia and Alzheimer's disease and related disorders (ADRD) for early detection and intervention strategies for cognitive health in aging populations.

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Research summary

The study aims to characterize cognitive decline trajectories and dementia risk factors in older Egyptian adults. This research is relevant as it addresses cognitive aging and dementia, which are significant aspects of longevity and age-related diseases, particularly in an understudied population.

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