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RESEARCH PAPER / 2026-04-20

Activating the vagus nerve-adrenal anti-inflammatory axis to delay aging: A randomized controlled trial protocol.

Chong Sun, Meihong Fu, Jiao Liu, Kebing Zheng, Shaoping Chen, Lunsha Deng, Yanping Zhuang, Kai Wang, Ruibao Ren, Chao Liang

Department of Acupuncture and Moxibustion, Haikou Hospital of Traditional Chinese Medicine, Haikou, 570000, China.Department of Acupuncture and Moxibustion, Haikou Hospital of Traditional Chinese Medicine, Haikou, 570000, China. · pubmed

Abstract

Aging is a primary risk factor for chronic diseases, yet safe and effective interventions remain limited. Traditional Chinese Medicine (TCM) highlights the role of acupuncture in health preservation, with ST36 (Zusanli) being a key acupoint for longevity. Preclinical studies suggest ST36 acupuncture modulates inflammation and oxidative stress, but robust clinical evidence is lacking. This trial aims to evaluate the efficacy of ST36 acupuncture in delaying aging and preventing age-related diseases through biomarkers and clinical outcomes.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that ST36 acupuncture can delay aging and prevent age-related diseases. The focus on a potential intervention to modulate inflammation and oxidative stress aligns with addressing root causes of aging, making it relevant to longevity research.

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