White adipose atrophy exacerbates cold stress and accelerates aging in male mice.

Zuojun Liu, Wenjing Hu, Xiaoqing Tan, Shimin Sun, Xin Huang, Yuan Meng, Nan Zhao, Ming Wang, Weiwei Wu, Minxian Qian, Xiaolong Tang, Qiuxiang Pang, Zimei Wang, Wen Su, Baohua Liu

Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Marshall Laboratory of Biomedical Engineering, International Cancer Center, National Health Commission Key Laboratory of Bone Aging, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Marshall Laboratory of Biomedical Engineering, International Cancer Center, National Health Commission Key Laboratory of Bone Aging, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China. · pubmed

Paper

Abstract

Adipose tissues are highly dynamic in response to environmental temperature changes. During aging, subcutaneous white adipose tissues (WAT) decreases, yet whether this atrophy exacerbates cold stress and triggers systemic aging remains unclear. Here we show that adipocyte-specific expression of the Lmna

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that adipocyte-specific expression of Lmna exacerbates cold stress and accelerates aging in male mice. This research is relevant as it explores the role of white adipose tissue atrophy in the aging process and its potential implications for systemic aging mechanisms.

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