Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.

Qi Zhu, Qingxia You, Jiaojiao Deng, Hongting Tang, Yuhan Hu, Yuanmeng Liao, Ying Miao

Department of Laboratory Medicine, The First Affiliated Hospital of Army Medical University of the People's Liberation Army of China, Chongqing, China. · pubmed

Paper

Abstract

Osteoarthritis (OA) is characterized by inflammation-driven chondrocyte senescence and extracellular-matrix degradation. However, the molecular mechanisms linking inflammatory stress to chondrocyte aging remain poorly understood. Here, we identify cinnamyl alcohol (CA) as a natural small-molecule compound that attenuates OA progression through polymeric immunoglobulin receptor (PIGR)-mediated signaling

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Research summary

Cinnamyl alcohol attenuates osteoarthritis progression through PIGR-mediated regulation of chondrocyte senescence and cartilage homeostasis. The paper addresses the molecular mechanisms linking inflammation and chondrocyte aging, which are relevant to the broader understanding of aging and age-related diseases.

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