From collapse to comeback: Luteolin rejuvenates nucleus pulposus progenitor cells via SIRT1/ATF5-UPRmt to reverse intervertebral disc degeneration cascade.

Huofeng Wu, Shuangjia Zai, Xuan You, Chen Liu, Zhaoyu Li, Zhengguang Li, Yuhui Mei, Benkui Hua, Yuping Tao, Yiming Wu, Liang Zhang

Department of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.Department of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China. · pubmed

Paper

Abstract

Intervertebral disc degeneration (IVDD) is a major contributor to low back pain (LBP) and one of the foremost causes of disability worldwide. Oxidative stress-induced senescence of nucleus pulposus progenitor cells (NPPC) and mitochondrial dysfunction are key drivers of IVDD. The mitochondrial unfolded protein response (UPR

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Research summary

Luteolin rejuvenates nucleus pulposus progenitor cells through the SIRT1/ATF5-UPRmt pathway to reverse intervertebral disc degeneration. This research addresses the underlying cellular mechanisms of aging-related degeneration, which is pertinent to longevity studies.

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