Mapping the landscape of Hutchinson-Gilford Progeria Syndrome research: A bibliometric analysis (1995-2025).

Atharva Kharul, Harshita Chhallani, Kshitij Jadhav, Asha Thomas, Ashwani Patil

Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra 411018, India; DPGU School of Pharmacy and Research, Maharashtra 411018, India. Electronic address: [email protected]. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra 411018, India; DPGU School of Pharmacy and Research, Maharashtra 411018, India. Electronic address: [email protected]. · pubmed

Paper

Abstract

Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare hereditary condition caused by germline de novo mutations of LMNA gene that synthesizes the toxic protein progerin and, therefore, compromises nuclear structure and expedites aging of cells. HGPS is fairly rare (estimated as 1 in 20 million people), but triggered a significant amount of academic interest due to the interplay between the disease and both research into rare diseases and studies of the aging process more generally.

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Research summary

The paper maps the research landscape of Hutchinson-Gilford Progeria Syndrome, highlighting its connections to aging mechanisms. The study is relevant as it explores a rare genetic condition that accelerates aging, providing insights into the biological processes underlying aging itself.

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