Differential DNA methylation clock ages across buffy coat (BC), peripheral blood mononuclear cells (PBMC), and saliva in individuals in early-to-mid adulthood.

Ryan Bruellman, Donald Evans, Andrew Smolen, Luke M Evans, Chandra A Reynolds

Genetics, Genomics and Bioinformatics, University of California Riverside, Riverside, CA, USA.Genetics, Genomics and Bioinformatics, University of California Riverside, Riverside, CA, USA. · pubmed

Paper

Abstract

Epigenetic aging prior to midlife is gaining interest as an intervenable period to address health and cognitive aging. Epigenetic changes may index DNA methylation aging rates, but methylation profiles may not be substitutable across tissues. We compared DNA methylation clocks and age acceleration in saliva, buffy coat (BC), and peripheral blood mononuclear cells (PBMC) collected in 91 individuals (7 unpaired, 20 siblings, 64 twins; 18 monozygotic (MZ), 14 dizygotic (DZ) pairs) from the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife1; Mean age = 30.90 years [range = 28.07-41.13]; 50.5% female). Across 15 DNA methylation clocks, chronological age and DNA methylation ages were moderately associated (mean Spearman correlations:

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Research summary

The paper claims that DNA methylation clocks vary across different tissues in early-to-mid adulthood. This research is relevant as it explores epigenetic aging, which may provide insights into the biological mechanisms of aging and potential interventions for longevity.

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