Multitissue, multi-time point transcriptomic atlas of aging in mice and rats.

Tea Shavlakadze, Kun Xiong, Romain Donne, Corissa McEwen, Abhilash Gadi, Matthew Wakai, Hunter Salmon, Jacob Treinish, Elias Pavlopoulos, Larry Proctor, Shuo Li, Nicole Negron, Min Ni, Yi Wei, Yu Bai, David J Glass

Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA. · pubmed

Paper

Abstract

To determine the genes and pathways that are up- or down-regulated in a consistent manner throughout the rodent lifespan, we generated a high N age-related gene expression atlas in mice and rats, by profiling 28 tissues in male and female C57BL/6J mice and 32 tissues in male Sprague Dawley rats (>5000 samples) over multiple time points. We identified age-related genes and pathways that change either early in life, at mid-age, late in life, or linearly throughout the animals' lifespan. Linear genes dominated many but not all tissues, and certain tissues were relatively spared from age-related changes. We explored common and different features of aging between tissues, sexes, and species. Given the expanse of our transcriptomic dataset, we believe that this study will serve as a useful resource for understanding the timing, tissue specificity, sex-specificity, and species specificity of age-related gene and pathway changes in mice and rats.

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Research summary

The paper claims to identify age-related genes and pathways that change consistently throughout the rodent lifespan. This research is relevant as it aims to elucidate the biological mechanisms of aging, which could contribute to understanding the root causes of aging and inform potential interventions for lifespan extension.

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