[Protective effect and mechanism of TSPAN9-mediated mitocytosis in interleukin-1β-induced rat chondrocyte senescence].

Quan Chen, Wacili Da, Naijia Luo, Bin Shen

Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China. · pubmed

Paper

Abstract

To investigate the regulatory role and molecular mechanisms of TSPAN9-mediated mitocytosis in an interleukin-1β (IL-1β)-induced rat chondrocyte senescence model, and to identify novel therapeutic targets for osteoarthritis (OA).

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Research summary

The paper investigates the protective effect of TSPAN9-mediated mitocytosis in chondrocyte senescence induced by IL-1β. This research is relevant as it explores mechanisms that could address cellular senescence, a fundamental aspect of aging and age-related diseases like osteoarthritis.

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